ADRENERGIC RECEPTORS IN CORONARY ARTERIES

Adrenergic receptors in coronary arteries.

Adrenergic Receptors in Human Atherosclerotic Coronary Arteries

Background—Adrenergic regulation of coronary vasomotion is balanced between 1-adrenergic–mediated ( 1-AR) constriction and 2-adrenergic–mediated ( 2-AR) relaxation. This study aimed at assessing the role of 2-ARs in normal, mildly atherosclerotic, and stenotic human coronary arteries. Methods and Results—During intracoronary (IC) infusion of increasing doses of the 2-AR agonist salbutamol (0.15...

Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries.

BACKGROUND Adrenergic regulation of coronary vasomotion is balanced between alpha1-adrenergic-mediated (alpha1-AR) constriction and beta2-adrenergic-mediated (beta2-AR) relaxation. This study aimed at assessing the role of beta2-ARs in normal, mildly atherosclerotic, and stenotic human coronary arteries. METHODS AND RESULTS During intracoronary (IC) infusion of increasing doses of the beta2-A...

Subtypes of /3-Adrenergic Receptors in Bovine Coronary Arteries

Whether large coronary artery dilation induced by /3-adrenergic stimulation is mediated by /3ior /32adrenergic receptors remains controversial. This problem is particularly difficult to address in vivo due to the concomitant increase in coronary blood flow with /3-adrenergic stimulation, which by itself can dilate large coronary arteries. To reconcile this problem, 5 calves were instrumented wi...

Autoradiographic Localization of / 3 - Adrenergic Receptors in Human Large Coronary Arteries

The distribution of j3-adrenergic receptors in sections of the human right and left coronary arteries and of the anterior intraventricular branch was studied by the use of combined in vitro radioreceptor binding and autoradiographic techniques. [125I]Cyanopindolol was used as a ligand for ,B-adrenergic receptors. Binding of the radioligand to sections of the three coronary arteries under study ...